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Hamed Mirzaei, [email protected] These authors have equally contributed to this work This article was submitted to Pharmacology of Anti-Cancer Drugs, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

91 Cardiovascular diseases often involve alterations in lipid and glucose metabolism

This review systematically analyzes the dual role of methionine-restricted diets in tumor development: on one hand, acting as a metabolic vulnerability target to induce tumor-specific death, and on the other hand, remodeling the tumor microenvironment through epigenetic reprogramming, while focusing on the challenges and optimization strategies in its clinical translation

70 A dose-dependent response of activated microglia and astrocytes was seen following direct LPS infusion into the fourth ventricle of the brains of male rats